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These group comparisons also show no significant difference between the groups. Table 4 shows descriptive statistics for the difference scores obtained by subtracting the hospital discharge score from the corresponding hospital admission score, which are presented with significance levels from tests for group differences. The respiratory rate, wheezing, and retraction difference scores show no difference between the groups, but the CXR difference scores show that the rhDNase group improved by 0.46 while the placebo group worsened by 0.60 (p < 0.001). Click Here
Correlation analysis of the ratings obtained from the two pediatric radiologists showed that there was substantial agreement between the two observers. The correlation for ratings of CXRs obtained at the time of hospital admission was 0.76; the correlation at the time of hospital discharge was 0.73. However, the radiologists differed systematically as shown by paired t test analysis. For the hospital admission CXRs, the mean ratings for the two observers were 2.68 and 1.85 (p < 0.0001); for the hospital discharge CXRs, the means were 2.77 and 1.95 (p < 0.0001). Because of the high correlations between the radiologists, the average score of the two radiologists was used as our primary outcome variable.
Table 4—Difference Measures Between Hospital Admission and Discharge
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